Celdara Medical – Program Highlight: ImmuType™
ImmuType™ is a Celdara Medical Enterprise focused on providing improved care for patients with systemic autoimmune disease. By supporting patient stratification and identifying treatment responders based on each patient’s unique molecular profile, ImmuType™ can improve the success rate, while reducing time and cost of clinical trials. Beyond enrollment, ImmuType™ can also support retrospective analysis of patient samples to garner pathway and mechanism of action (MoA) insights and inform clinical and market strategy.
Using transcriptome data, ImmuType™ applies a proprietary algorithm to classify patients by their molecular signatures into specific subtypes. Stratification identifies likely responders (or non-responders), enabling value-creating inclusion and exclusion criteria. Stratification also provides insight into shared underlying drivers of heterogeneous systemic autoimmune diseases, allowing drug developers to treat disease mechanisms rather than symptoms.
Initially born out of a collaboration with Dartmouth College and focused on systemic sclerosis, ImmuType™ is now actively expanding offerings to other systemic autoimmune diseases. To date, ImmuType™ has supported eight trials in systemic sclerosis with six programs under active consideration.We are currently supporting 6 scleroderma trials raging from Phases I through III. In addition, the ImmuType™ team has generated predictive patient stratification data sets for Systemic Lupus Erythematosus (SLE) and Dermatomyositis (DM). The ImmuType™ platform can be leveraged widely across autoimmune disorders to assist in clinical trial design, and ultimately advance innovative therapeutics to patients with high unmet need – faster, safer, and with far more statistical power.
The ImmuType™ team includes autoimmune disease experts as well as experts in bioinformatics and therapeutic development.
Michael Whitfield, PhD. ImmuType Inventor and Celdara Medical Scientific Founder
Department Chair, Biomedical Data Science, Geisel School of Medicine at Dartmouth
Joana Murad Mabaera, PhD. Technical Lead, Executive Director of R&D, Celdara Medical
Formerly: Norris Cotton Cancer Center and University of Sao Paulo
Viktor Martyanov, PhD. Bioinformaticist, Celdara Medical
Formerly: Geisel School of Medicine at Dartmouth
Jake Reder, PhD. Co-Founder & CEO, Celdara Medical
Formerly: Dartmouth, Cabot Corp., PolyTechnos Venture-Partners
Brandy Houser, PhD. Business Development, NY/NJ Site Head, Celdara Medical
Formerly: Brandon Capital Partners; Partners Healthcare; Harvard Medical School
Jing Gong, PhD. Business Development, Associate Director, Celdara Medical
Formerly: Translational Therapeutics Accelerator and Columbia University